Read the Patient Information Leaflet if available from your pharmacist before you start taking sildenafil and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
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If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
Lifestyle changes like exercising regularly, eating a heart-healthy diet, and avoiding alcohol and smoking (both of which can damage blood vessels and nerves that produce a healthy erection) can also help with symptoms of ED.
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VIAGRA should not be used with REVATIO or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca® [tadalafil])
Sildenafil is in a class of medications called PDE5 inhibitors. These drugs restrict the action of phosphodiesterase enzymes, which break down cyclic guanosine monophosphate.
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All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:
Sildenafil should not be taken for ED more than once in a 24-hour period. But if you have certain medical conditions or are taking other drugs, your doctor may recommend that you take this drug less often than once a day.
Similar to grapefruit, medications known direto da fonte as cytochrome P450 (CP450) inhibitors and substrates can delay the effects of sildenafil and increase your chances of experiencing side effects. CP450 inducers, such as modafinil, reduce the effects of sildenafil if taken at the same time.
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and increased penile response to sexual stimulation.
Side effects from sildenafil: Taking sildenafil with certain medications raises your risk for side effects from sildenafil. This is because the amount of sildenafil in your body is increased. Examples of these drugs include:
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